SNAP-8 10mg
Synthetic octapeptide researched for mimicking SNAP-25 to attenuate muscle contraction signaling and soften dynamic facial lines.
Mechanism
Competitively mimics the N-terminal end of SNAP-25 to destabilize the SNARE complex, thereby attenuating calcium-dependent acetylcholine exocytosis without causing complete neuromuscular blockade.
Dosing
Documented laboratory protocols establish an initial experimental dose of 330 mcg administered once daily.
Reconstitution
Reconstituting a 10 mg vial with 3.0 mL of bacteriostatic water yields an approximate working concentration of 3.33 mg/mL (33.3 mcg per U-100 unit).
Storage
Store the lyophilized peptide powder frozen at -20°C shielded from light, and keep the reconstituted solution refrigerated between 2°C and 8°C for up to 28 days without freezing.
Mix & measure SNAP-8 10mg
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure SNAP-8 10mg
Vial strength → BAC water → target dose
Common vial sizes
Label claim
Total doses in vial: 30.3
U-100 syringe: 100 units = 1 mL
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Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
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Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Weeks 1–4 | 330 mcg (1× daily) | ~10 units (0.10 mL) |
| Weeks 5–8 | 500 mcg (1× daily) | ~15 units (0.15 mL) |
| Weeks 9–12 | 1,000 mcg (1× daily) | ~30 units (0.30 mL) |
| Weeks 13–16 (optional) | 1,000 mcg (1× daily) | ~30 units (0.30 mL) |
Reconstitution Steps
- 1
Draw exactly 3.0 mL of sterile bacteriostatic water into a reconstitution syringe.
- 2
Introduce the diluent slowly against the inside glass wall of the 10 mg SNAP-8 vial to minimize foaming.
- 3
Swirl or rotate the vial gently until the lyophilisate is fully dissolved, avoiding vigorous shaking.
- 4
Affix a label noting the reconstitution date and concentration, then transfer to refrigerated storage at 2–8°C protected from light.
Supplies Needed
Peptide Vial
Provides 10 mg of lyophilized SNAP-8 per unit for laboratory investigation.
Insulin Syringes (U-100)
Used for precise measurement and daily delivery of low-volume research doses.
Bacteriostatic Water
Serves as the sterile, preserved diluent to reconstitute the peptide cake.
Alcohol Swabs
Used to sanitize rubber vial stoppers and research application surfaces before handling.
Why researchers study it
Expression wrinkle appearance
Muscle contraction signaling
Anti-aging skincare formulation
Topical peptide behavior
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
SNAP-8, chemically designated as Acetyl Octapeptide-3, represents an elongated analogue of the hexapeptide Argireline designed to influence neuromuscular signaling pathways. In scientific literature, it is primarily recognized and evaluated as a topical cosmetic peptide targeting the visibility of expression wrinkles formed through repetitive facial muscle movements. While predominantly formulated for external topical cosmetic applications such as anti-aging serums and creams, certain experimental laboratory protocols explore its systemic or subcutaneous behavior. Because it is non-paralytic, research models evaluate its potential to temper rather than completely block neuromuscular transmission, presenting an alternative profile compared to potent botulinum neurotoxins.
References
- 1.European Commission, CosIng Database, 2023 — Acetyl Octapeptide-3 cosmetic ingredient inventory and functions
- 2.Lipotec Technical Report, Cosmetic Science Literature, 2005 — SNAP-8 proposed mechanism and topical efficacy data
- 3.Blanes-Mira et al., Journal of Cosmetic Science, 2002 — SNARE complex modulation and acetylcholine release attenuation by synthetic peptides
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.
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