SLU-PP-332 5mg
Preclinical synthetic pan-ERR agonist studied as an exercise mimetic for mitochondrial oxidation and metabolic regulation.
Mechanism
Acts as a synthetic pan-agonist across estrogen-related receptors (ERRα, ERRβ, and ERRγ) to induce an aerobic-exercise gene program and upregulate mitochondrial respiration.
Dosing
Preclinical murine protocols document an initial regimen of 625 mcg administered twice daily (1,250 mcg per day total).
Reconstitution
Diluting a 5 mg vial with 3.0 mL of bacteriostatic water creates an approximate concentration of 1.67 mg/mL.
Storage
Store unmixed lyophilized vials frozen at -20 °C, and keep the reconstituted solution refrigerated between 2 °C and 8 °C protected from light without refreezing.
Mix & measure SLU-PP-332 5mg
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure SLU-PP-332 5mg
Vial strength → BAC water → target dose
Common vial sizes
Label claim
Total doses in vial: 8.0
U-100 syringe: 100 units = 1 mL
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Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
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Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Weeks 1–2 | 625 mcg (2× daily · 1,250 mcg/day) | 37.5 units (0.375 mL) per dose |
| Weeks 3–8 | 1,250 mcg (2× daily · 2,500 mcg/day) | 75 units (0.75 mL) per dose |
Reconstitution Steps
- 1
Aspirate exactly 3.0 mL of bacteriostatic water using a sterile syringe.
- 2
Introduce the diluent slowly against the inside glass wall of the vial to minimize agitation.
- 3
Swirl the vial gently until the cake has fully dissolved without shaking.
- 4
Affix a label noting concentration and date, then transfer immediately to refrigerated storage at 2–8 °C away from light.
Supplies Needed
Peptide Vial
SLU-PP-332 lyophilized powder (5 mg vial)
Insulin Syringes (U-100)
1 mL syringes used to accurately draw and administer unit-level doses
Bacteriostatic Water
3.0 mL of sterile bacteriostatic diluent required per 5 mg vial
Alcohol Swabs
Antiseptic wipes used to sterilize the vial stopper and injection interface
Why researchers study it
Fat loss and weight management mechanisms
Running endurance and physical capacity enhancement
Mitochondrial biogenesis and lipid oxidation pathways
Myocardial support and cardiac failure models
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
SLU-PP-332 is an investigational small-molecule agonist developed to target estrogen-related receptors, functioning as an experimental metabolic modulator. Synthesized to evaluate the signaling pathways underlying physical endurance, it engages cellular machinery comparable to sustained aerobic physical exertion. Preclinical research primarily focuses on how this agent alters energetic balance, stimulates fatty acid combustion, and drives transcriptional changes within skeletal muscle and myocardial tissues. Because all existing scientific findings originate exclusively from rodent models, translational parameters in human systems remain entirely unestablished.
References
- 1.ACS Chemical Biology, 2023 — Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic-exercise response and enhances exercise capacity
- 2.J. Pharmacology and Experimental Therapeutics, 2024 — A synthetic ERR agonist (SLU-PP-332) alleviates metabolic syndrome in mice
- 3.Circulation, 2024 — Novel pan-ERR agonists ameliorate heart failure through enhanced cardiac fatty-acid metabolism and mitochondrial function
- 4.American Journal of Pathology, 2023 — Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.
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