Sermorelin 10mg
A truncated synthetic GHRH analog studied for its ability to stimulate endogenous pituitary growth hormone secretion in nightly research protocols.
Mechanism
Binds selectively to pituitary GHRH receptors to trigger episodic, endogenous growth hormone secretion while preserving physiological somatostatin feedback control.
Dosing
Documented laboratory protocols initiate evaluation with an introductory nightly dose of 100 mcg administered subcutaneously prior to rest.
Reconstitution
Reconstituting a 10 mg vial with 3.0 mL of bacteriostatic water yields an approximate working concentration of 3.33 mg/mL (3,333 mcg/mL).
Storage
Store the unmixed lyophilized vial refrigerated between 2 and 8 °C protected from light, and keep the reconstituted solution refrigerated at 2 to 8 °C without freezing, utilizing it within 10 to 14 days.
Mix & measure Sermorelin 10mg
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure Sermorelin 10mg
Vial strength → BAC water → target dose
Total doses in vial: 100.0
U-100 syringe: 100 units = 1 mL
Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Weeks 1–2 | 200 mcg (1× nightly) | ~6 units (0.06 mL) |
| Weeks 3–4 | 300 mcg (1× nightly) | ~9 units (0.09 mL) |
| Weeks 5–6 | 400 mcg (1× nightly) | ~12 units (0.12 mL) |
| Weeks 7–8 | 500 mcg (1× nightly) | ~15 units (0.15 mL) |
Reconstitution Steps
- 1
Aspirate exactly 3.0 mL of sterile bacteriostatic water using a fresh syringe.
- 2
Introduce the diluent gently along the interior glass wall of the 10 mg vial to avoid peptide shearing and excess foam.
- 3
Swirl the vial with slow, circular motions until the lyophilized cake is fully dissolved without vigorous agitation.
- 4
Affix a label noting the reconstitution date and resulting 3.33 mg/mL concentration, then place immediately into refrigerated storage at 2–8 °C away from light.
Supplies Needed
Peptide Vial
Lyophilized Sermorelin acetate target compound (10 mg)
Insulin Syringes (U-100)
Calibrated 1 mL syringes for precise measurement of microgram aliquots
Bacteriostatic Water
Sterile diluent with 0.9% benzyl alcohol preservative (3.0 mL required per vial)
Alcohol Swabs
70% isopropyl alcohol prep pads for disinfecting vial stoppers and injection surfaces
Why researchers study it
Endogenous pulsatile GH and downstream IGF-1 induction
Somatotropic regulation during deep slow-wave sleep cycles
Adipose lipolysis and lean tissue metabolic pathways
Endocrine signaling changes during age-related hormonal senescence
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
Sermorelin is a synthetic peptide representing the first 29 amino acids of human growth hormone-releasing hormone, corresponding to the functional region responsible for pituitary stimulation. By interacting directly with somatotropes in the anterior pituitary gland, it prompts the natural release of endogenous somatotropin while maintaining normal endocrine feedback mechanisms. In laboratory and experimental models, sermorelin serves as a non-exogenous route to assess somatotropic function without completely suppressing native feedback loops. Unlike recombinant somatropin, its action depends heavily upon an intact, functioning pituitary axis and respects normal physiological inhibitory signals, notably somatostatin regulation.
References
- 1.Prakash & Goa, Drugs, 1999 — Review of sermorelin in the diagnosis and management of idiopathic growth hormone deficiency
- 2.RxList, Sermorelin Acetate Monograph, 2008 — Clinical monograph covering sermorelin preparation, dosing considerations, and discontinuation context
- 3.Van Cauter et al., Sleep, 1998 — Endogenous growth hormone secretion patterns and relationship to slow-wave sleep physiology
- 4.Mayo Clinic, Clinical Pharmacology, 2020 — Overview of sermorelin injection route, handling, and preservation parameters
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.
Related protocols
View allNAD+ 500mg
Essential metabolic coenzyme studied for sustaining cellular bioenergetics, mitochondrial respiration, and longevity pathways.
View ProtocolBronchogen 20mg
Synthetic short bioregulator tetrapeptide Ala-Glu-Asp-Leu investigated in preclinical airway models and epigenetic regulation.
View ProtocolGLOW 70mg (50+10+10 mg)
A multi-peptide blend combining GHK-Cu, TB-500, and BPC-157 investigated for cellular repair, collagen synthesis, and systemic healing.
View Protocol