Semax 10mg
A synthetic heptapeptide ACTH(4-10) derivative investigated in preclinical models for neurotrophic signaling, focus, and neuroprotection.
Mechanism
Semax stimulates the expression of brain-derived neurotrophic factor (BDNF) and its TrkB receptor while modulating monoaminergic and central melanocortin neurotransmission without triggering systemic corticosteroid release.
Dosing
Standard laboratory protocols report an initial daily administration of 0.5 mg (500 mcg), corresponding to roughly 15 units of the diluted solution.
Reconstitution
Reconstituting a 10 mg vial with 3.0 mL of bacteriostatic water yields an operating concentration of approximately 3.33 mg/mL (33.3 mcg per U-100 unit).
Storage
Store the unmixed lyophilized powder at -20°C, and maintain the reconstituted liquid between 2°C and 8°C protected from light without refreezing.
Mix & measure Semax 10mg
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure Semax 10mg
Vial strength → BAC water → target dose
Common vial sizes
Label claim
Total doses in vial: 20.0
U-100 syringe: 100 units = 1 mL
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Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
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Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Weeks 1–4 | 0.5 mg (500 mcg, 1× daily) | ~15 units (0.15 mL) |
| Weeks 5–8 | 1 mg (1,000 mcg, 1× daily) | ~30 units (0.30 mL) |
Reconstitution Steps
- 1
Aseptically draw 3.0 mL of bacteriostatic water using a sterile syringe.
- 2
Introduce the liquid slowly along the inside glass wall of the vial to minimize foaming.
- 3
Gently rotate and swirl the vial until the lyophilized pellet is completely dissolved without shaking.
- 4
Record the mixing date and working concentration on the vial label, then store at 2–8°C away from direct light.
Supplies Needed
Peptide Vial
Provides 10 mg of lyophilized Semax for experimental evaluation.
Insulin Syringes (U-100)
Used for precise measurement and subcutaneous administration of micro-volume research doses.
Bacteriostatic Water
Serves as the sterile solvent containing 0.9% benzyl alcohol to reconstitute the peptide.
Alcohol Swabs
Disinfects the rubber vial stopper and the target injection surface prior to handling.
Why researchers study it
Cognition & nootropic exploration
Neuronal survival during ischemic stress
Attentional performance and mental endurance
Neurotrophin signaling and stress response pathways
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
Semax is an engineered peptide derivative patterned after a fragment of adrenocorticotropic hormone, specifically ACTH(4-10), extended at the C-terminus with a Pro-Gly-Pro tripeptide motif. This structural modification was designed to dramatically improve metabolic stability and resist enzymatic degradation in biological tissues. In laboratory models, it demonstrates central nervous system activity while deliberately lacking intrinsic hormonal or corticotropic stimulation. Preclinical research focuses extensively on the peptide's ability to stimulate neurogenesis and support cognitive processes. Investigational models assess its role in elevating neurotrophin expression, modulating central neurotransmitter systems including dopamine and serotonin, and defending neuronal networks against metabolic or ischemic compromise. While predominantly recognized in Eastern European clinical literature where an intranasal delivery method is standard, Semax is handled purely as an experimental reference compound in Western laboratories. Research protocols commonly utilize subcutaneous administration frameworks to quantify systemic bioavailability and neurocognitive biomarkers.
References
- 1.Nootropic and Comparative Physiology (PubMed) — Semax neuroprotective and nootropic activity and BDNF involvement
- 2.Journal of Molecular Neuroscience — Structure of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and its melanocortin basis
- 3.Neuroscience (PMC) — Semax increases BDNF and TrkB expression in the rat hippocampus
- 4.Restorative Neurology and Neuroscience — Semax effects on monoaminergic systems, attention and cognitive function
- 5.Cochrane / PubMed — Semax in acute ischemic stroke clinical reports
- 6.Drug Approval Registry (Russia) — Semax registration as a medicine for cerebrovascular and cognitive disorders
- 7.Intranasal Delivery Review (PubMed) — Intranasal administration of Semax for nose-to-brain peptide delivery
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.
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