CJC-1295 DAC 5mg
Long-acting synthetic GHRH analog paired with Drug Affinity Complex to sustain growth hormone release in laboratory models.
Mechanism
The peptide binds selectively to pituitary somatotroph GHRH receptors, while its Drug Affinity Complex covalently tethers to serum albumin to maintain persistent, non-pulsatile secretion of growth hormone and downstream IGF-1.
Dosing
Published experimental handling outlines an initial investigative baseline of 300 mcg administered twice weekly, titrating systematically according to study criteria.
Reconstitution
Reconstituting the 5 mg lyophilized powder with 2.0 mL of bacteriostatic water yields a finished working concentration of 2.5 mg/mL (25 mcg per U-100 unit).
Storage
Store the unmixed lyophilized vial at -20 °C, and once reconstituted, maintain the solution between 2 °C and 8 °C protected from light without refreezing.
Mix & measure CJC-1295 DAC 5mg
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure CJC-1295 DAC 5mg
Vial strength → BAC water → target dose
Total doses in vial: 16.7
U-100 syringe: 100 units = 1 mL
Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Weeks 1–2 | 300 mcg (0.3 mg) twice weekly | 12 units (0.12 mL) |
| Weeks 3–4 | 500 mcg (0.5 mg) twice weekly | 20 units (0.20 mL) |
| Weeks 5–6 | 750 mcg (0.75 mg) twice weekly | 30 units (0.30 mL) |
| Weeks 7–12 | 1000 mcg (1 mg) twice weekly | 40 units (0.40 mL) |
Reconstitution Steps
- 1
Draw 2.0 mL of bacteriostatic water into a sterile syringe.
- 2
Release it slowly down the vial's inner wall to limit foaming.
- 3
Swirl or roll gently until fully dissolved — don't shake.
- 4
Label with the date and concentration, then refrigerate at 2–8 °C (35.6–46.4 °F), shielded from light.
Supplies Needed
Peptide Vial
CJC-1295 DAC 5 mg lyophilized peptide
Insulin Syringes (U-100)
1 mL U-100 syringes for measurement and administration
Bacteriostatic Water
Diluent for peptide reconstitution (2.0 mL per vial)
Alcohol Swabs
Sanitizing vial stoppers and preparation sites
Why researchers study it
GH & IGF-1 support
Body composition & lipolysis
Tissue repair & recovery
Sleep & slow-wave activity
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
CJC-1295 DAC is a synthetic growth-hormone-releasing hormone derivative engineered with a Drug Affinity Complex modification. This specific functional group binds covalently to endogenous serum albumin following administration, markedly slowing renal filtration and enzymatic breakdown compared to native hormones. As a consequence of this prolonged circulation, experimental settings observe a persistent, non-pulsatile elevation of growth hormone and insulin-like growth factor 1, often contrasted with the transient secretory pulses created by standard peptide formulations. In investigative biochemistry, this continuous activation provides an experimental framework for analyzing downstream somatotropic signaling without necessitating daily dosing schedules. Researchers explore the resulting cascade to observe physiological adaptations involving cellular nitrogen retention, lipid mobilization pathways, and peripheral tissue remodeling. The compound serves as an important benchmark in the study of structural half-life enhancement and pituitary receptor occupancy.
References
- 1.Teichman SL et al., J Clin Endocrinol Metab, 2006 — Prolonged stimulation of GH and IGF-1 secretion by CJC-1295
- 2.Ionescu M, Frohman LA, J Clin Endocrinol Metab, 2006 — Pulsatile and continuous effects on GH and IGF-1 elevation
- 3.Alba M et al., Am J Physiol Endocrinol Metab, 2006 — Mechanistic GHRH-receptor activation in knockout animal models
- 4.Ayuk J, Sheppard MC, Postgrad Med J, 2006 — Growth hormone physiology and excessive GH/IGF-1 signaling
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.