Lipo-C 1250mg (10 mL)
A pre-mixed lipotropic solution pairing methionine, inositol, choline, and vitamin B12 to investigate hepatic lipid clearance and energy pathways.
Mechanism
Lipo-C delivers methyl donors and essential cofactors that facilitate hepatic very-low-density lipoprotein export, mitochondrial fatty acid translocation, and cellular one-carbon metabolism.
Dosing
Standard laboratory protocols document starting evaluations at an initial draw of 0.5 mL (delivering roughly 63 mg combined MIC and 500 mcg B12) administered once or twice weekly.
Reconstitution
The compound is supplied as a ready-to-use aqueous solution requiring no bacteriostatic water, yielding an approximate working concentration of 125 mg/mL total MIC and 1000 mcg/mL vitamin B12.
Storage
Store refrigerated between 2°C and 8°C in a dark environment to prevent light-induced degradation of cyanocobalamin, discarding according to sterile beyond-use dates.
Mix & measure Lipo-C 1250mg (10 mL)
Pre-filled with this protocol's recommended BAC water and documented starting dose — edit any field to run your own numbers.
Mix & measure Lipo-C 1250mg (10 mL)
Vial strength → BAC water → target dose
Common vial sizes
Label claim
Total doses in vial: —
U-100 syringe: 100 units = 1 mL
Reconstitution math only — not dosing advice. U-100 syringe: 100 units = 1 mL. Advanced calculator →
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Dosing Chart
| Phase / Day(s) | Dose & Frequency | Volume (U-100 units / mL) |
|---|---|---|
| Initial Evaluation | ~31 mg MIC + ~250 mcg B12 (1x weekly) | 25 units (0.25 mL) |
| Standard Starting Dose | ~63 mg MIC + ~500 mcg B12 (1-2x weekly) | 50 units (0.50 mL) |
| Intermediate Protocol | ~94 mg MIC + ~750 mcg B12 (1-2x weekly) | 75 units (0.75 mL) |
| High-Range Protocol | ~125 mg MIC + ~1000 mcg B12 (1-2x weekly) | 100 units (1.00 mL) |
Reconstitution Steps
- 1
Do not add any diluent or bacteriostatic water, as Lipo-C is pre-compounded as an injectable sterile liquid.
- 2
Inspect the vial clarity; verify that the liquid is a uniform, clear pink-to-red solution free of precipitate or cloudiness.
- 3
Sanitize the rubber vial septum with a sterile 70% isopropyl alcohol wipe and allow it to dry completely.
- 4
Using a sterile syringe, draw the planned research volume (e.g., 0.5 mL to 1.0 mL) directly from the multi-dose vial.
- 5
Return the multi-dose vial immediately to refrigeration (2–8°C) shielded from direct light exposure.
Supplies Needed
Peptide Vial
Pre-filled 10 mL multi-dose vial containing 1250 mg total MIC and 10,000 mcg vitamin B12 solution.
Insulin Syringes (U-100)
Used for precise measurement and administration of liquid draw volumes (typically 0.25 mL to 1.0 mL).
Bacteriostatic Water
Not required; solution is pre-constituted and ready for use directly from the manufacturer.
Alcohol Swabs
Used to thoroughly sterilize the multi-dose vial stopper and equipment contact surfaces.
Why researchers study it
Hepatic lipid processing and VLDL export mechanisms
Cellular methyl donor and one-carbon metabolic pathways
Mitochondrial fatty acid beta-oxidation dynamics
Correction and evaluation of vitamin B12 cellular status
These describe what is being studied, not proven benefits, approved uses, or promised results.
Overview
Lipo-C is an injectable multi-nutrient formulation consisting of lipotropic factors—specifically methionine, inositol, and choline (commonly referred to as MIC)—compounded alongside vitamin B12 (cyanocobalamin) and occasionally L-carnitine. Classified biochemically as a lipotropic nutrient mixture rather than a peptide sequence, the solution is designed to supply active metabolic cofactors directly without relying on gastrointestinal absorption. In experimental models and laboratory literature, the blend is widely evaluated for its capacity to assist in hepatic fatty acid mobilization, methyl group transfer, and cellular energy generation. Because choline and methionine are vital elements in the assembly of very-low-density lipoproteins and in the regeneration of S-adenosylmethionine, their combined administration serves as a benchmark for exploring cellular lipid management. While foundational nutritional science supports the biochemical functions of its individual constituents, systematic evidence for fat loss driven solely by the complete injected mixture remains scarce. Consequently, research environments utilize Lipo-C primarily to explore baseline metabolic repletion, hepatic transport, and micronutrient interactions under controlled nutritional conditions.
References
- 1.NIH Office of Dietary Supplements, Fact Sheet, 2021 — Choline's role in VLDL export and hepatic fat metabolism
- 2.NIH Office of Dietary Supplements, Fact Sheet, 2021 — Vitamin B12 cofactor roles and light sensitivity
- 3.NIH Office of Dietary Supplements, Fact Sheet, 2021 — Carnitine shuttling of fatty acids into mitochondria
- 4.Zeisel SH, da Costa KA, Nutr Rev, 2009 — Choline essentiality and reversal of hepatic steatosis
- 5.Rinella ME, Green RM, J Hepatol, 2004 — Methionine-choline-deficient dietary model and fat export impairment
- 6.Unfer V et al., Int J Endocrinol, 2016 — Myo-inositol impacts on insulin-resistance markers
- 7.Pooyandjoo M et al., Obes Rev, 2016 — Meta-analysis of L-carnitine administration on body weight
- 8.U.S. FDA, Regulatory Guidance, 2020 — Overview of compounded pharmaceutical regulatory standards
Supplies Needed
Suggested supplier
Research use only. Listing a supplier is not an endorsement of any protocol on this site, and nothing sold there is approved for human use.
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