AHK-Cu 50mg

1. 1

   Clean the rubber stoppers of both the AHK-Cu vial and bacteriostatic water vial using sterile alcohol prep pads and allow them to dry fully.

2. 2

   Draw 2.0 mL of bacteriostatic water using a sterile syringe.

3. 3

   Insert the needle into the AHK-Cu vial at a slight angle and direct the stream gently down the interior glass wall.

4. 4

   Swirl the vial gently until the lyophilized cake is fully dissolved, yielding a clear solution with a faint blue tint; avoid vigorous shaking.

5. 5

   Place the reconstituted solution in refrigerated storage at 2–8 °C protected from light.

Overview

AHK-Cu, or Copper Tripeptide-3, is a synthetic copper-peptide complex composed of L-alanyl-L-histidyl-L-lysine coordinated with a divalent copper ion. Positioned chemically within the same structural class as GHK-Cu, this compound is primarily recognized in preclinical literature for its investigation into dermal tissue biology and hair follicle dynamics. While lyophilized vials exist across peptide research channels, the molecule lacks clinical human trials and remains strictly a subject of experimental inquiry. Scientific interest in AHK-Cu originated from cellular assays examining dermal papilla activity and follicle shaft elongation. Due to its hydrophilic composition, patent literature historically emphasized its suitability for topical skin permeation rather than parenteral application. Much of the wider physiological data attributed to AHK-Cu is largely derived by analogy from GHK-Cu in vivo models, leaving its standalone injectable profile largely uncharacterized. In laboratory environments, reconstitution requires careful handling to maintain molecular stability and prevent the dissociation of the coordinate copper bond. Because documented community and patent research doses are exceptionally small relative to standard 50 mg vial sizes, experimental measurements demand meticulous volumetric dilution and precision handling.

1. 1.Pyo et al., Archives of Pharmacal Research, 2007 — Effect of tripeptide-copper complex on human hair growth in vitro
2. 2.Pickart & Margolina, International Journal of Molecular Sciences, 2018 — Regenerative and protective actions of the GHK-Cu peptide
3. 3.Pickart, Journal of Biomaterials Science, Polymer Edition, 2008 — The human tri-peptide GHK and tissue remodeling
4. 4.Pickart, US Patent 5,550,183, 1996 — Metal-peptide compositions and methods for stimulating hair growth
5. 5.Pallenberg et al., US Patent 5,538,945, 1996 — Stimulation of hair growth by peptide copper complexes
6. 6.Maquart et al., Journal of Clinical Investigation, 1993 — In vivo stimulation of connective tissue accumulation by GHK-Cu in rat wounds
7. 7.Siméon et al., Journal of Investigative Dermatology, 2000 — Modulation of glycosaminoglycans and small proteoglycans in wounds by GHK-Cu
8. 8.Swaim et al., American Journal of Veterinary Research, 1996 — Effect of locally injected medications on pad wound healing in dogs
9. 9.Ma et al., Life Sciences, 2019 — Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis
10. 10.Maquart et al., FEBS Letters, 1988 — Stimulation of collagen synthesis in fibroblast cultures by GHK-Cu
11. 11.Parker et al., Otolaryngology–Head and Neck Surgery, 2013 — Effects of topical copper tripeptide complex on wound healing in irradiated rats

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